Sie suchten nach: 5-Aminolevulinic+acid+hydrochloride

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Anti-ALAS2 Rabbit Polyclonal Antibody (Cy5®)

Artikel-Nr: (BOSSBS-9516R-CY5)

Lieferant: Bioss

Beschreibung: 5-aminolevulinate synthase 1 (ALAS-H) and 2 (ALAS-E) are two isoforms of ALAS, an enzyme catalyzing the first step of the heme biosynthetic pathway in mammals. The erythroid-specific isoenzyme, ALAS-E, regulates the first step of hematopoietic cell differentation and iron metabolism in the liver. ALAS-H is a housekeeping protein which mediates synthesis of early heme in the mitochondria of most cells. Succinyl CoA associates with ALAS-E in protein conformation change and translocation of ALAS-E into the mitochondria and does not interact with ALAS-H. The ALAS-E 5'-flanking region contains binding sites for nuclear activators such as GATA-1, NF-E2 and EKLF. Since the ALAS gene maps to the X chromosome, mutation of the gene leads to the pyridoxine-refractory X-linked sideroblastic anemia.

UOM: 1 * 100 µl

Aktion

N/A Stück

Anti-ALAS2 Rabbit Polyclonal Antibody (FITC (Fluorescein Isothiocyanate))

Artikel-Nr: (BOSSBS-9516R-FITC)

Lieferant: Bioss

UOM: 1 * 100 µl

Aktion

N/A Stück

Anti-ALAS1 Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-9527R-HRP)

Lieferant: Bioss

UOM: 1 * 100 µl

Aktion

N/A Stück

Anti-ALAD Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI29-613)

Lieferant: ProSci Inc.

Beschreibung: The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria.The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternatively spliced transcript variants encoding different isoforms have been identified.

UOM: 1 * 50 µG

Aktion