Sie suchten nach: Chiral+Technologies

Artikel-Nr: (BWRLBS2971)

Lieferant: Bioworld Technology

Beschreibung: Synthetic peptide, corresponding to amino acids 256-3111 of Human Myotubularin.

UOM: 1 * 100 µG

Aktion

Artikel-Nr: (BWRLBS2927)

Lieferant: Bioworld Technology

Beschreibung: Synthetic peptide, corresponding to amino acids 50-100 of Human GCSm-gamma.

UOM: 1 * 100 µG

Aktion

Artikel-Nr: (BWRLBS2450)

Lieferant: Bioworld Technology

Beschreibung: Synthetic peptide, corresponding to amino acids 851-900 of Human EphB6.

UOM: 1 * 100 µG

Aktion

Artikel-Nr: (STMC100-1281)

Lieferant: STEMCELL Technologies

Beschreibung: Supplement (50X) for the serum-free culture of neurons.

UOM: 1 * 100 mL

New Product Aktion

 This is a MarketSource item. Additional charges may apply

Lieferant: STEMCELL Technologies

Beschreibung: Macrophage colony-stimulating factor (M-CSF) is a homodimeric glycoprotein growth factor that regulates proliferation and differentiation of myeloid hematopoietic progenitor cells to mononuclear phagocytic cell lineages, including monocytes, macrophages, and osteoclasts. M-CSF is a crucial factor for the development of tissue-resident macrophages in most tissues (Ginhoux and Jung). It is required for the maturation and activation of monocytes and macrophages, and regulates inflammatory responses in conjunction with other stimuli such as IFN-γ, LPS, and IL-4 (Murray <i>et al.</i>). M-CSF is also required for bone resorption by osteoclasts, and is involved in the development and regulation of the placenta, mammary gland, and brain. M-CSF is produced by monocytes, fibroblasts, osteoclasts, stromal cells, endothelial cells, and tumor cells (Chockalingam and Ghosh). M-CSF exerts its biological effects by signaling through a receptor tyrosine kinase (CSF-1R or M-CSF-R) encoded by the c-fms proto-oncogene (Hamilton). CSF-1R shares similar structural features with other growth factor receptors, including the stem cell factor (SCF) receptor, platelet-derived growth factor receptor (PDGF-R), and Flt3/Flk-2 receptor tyrosine kinase. Stimulation of the CSF-1R upon binding to M-CSF activates MAPK, PI3K, and PLCγ signaling pathways (Chockalingam and Ghosh). Human and mouse M-CSF sequences are highly conserved both at nucleotide and amino acid levels (80% homology; DeLamarter <i>et al.</i>).

Artikel-Nr: (STMC78122.1)

Lieferant: STEMCELL Technologies

Beschreibung: TRAIL (TNF-related apoptosis-inducing ligand) belongs to the tumor necrosis factor (TNF) superfamily and is associated with initiating apoptosis. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors, which recruits the Fas-associated death domain (FADD) and activates caspases 8 and 10, which eventually leads to apoptosis (Pitti <i>et al.</i>; Wiley <i>et al.</i>; Zauli and Secchiero). It has been shown that mice lacking the expression of TRAIL have defects in thymocyte apoptosis and negative selection, and these mice had increased susceptibility to autoimmune diseases (Lamhamedi-Cherradi <i>et al.</i>).

UOM: 1 * 50 µG

Aktion

 This is a MarketSource item. Additional charges may apply

Lieferant: STEMCELL Technologies

Beschreibung: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang <i>et al.</i>). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk <i>et al.</i>).

Artikel-Nr: (STMC100-0386)

Lieferant: STEMCELL Technologies

Beschreibung: Culture medium kit for initiation, growth, and differentiation of human liver organoids.

UOM: 1 * 1 KIT

Aktion

 This is a MarketSource item. Additional charges may apply

Lieferant: STEMCELL Technologies

Beschreibung: Serum-free medium kit for highly efficient SMAD inhibition-mediated neural induction of human ES and iPS cells.

Lieferant: STEMCELL Technologies

Beschreibung: Amine-labelling fluorescent dye for live/dead staining of mammalian cells - 100 tests.

Lieferant: STEMCELL Technologies

Beschreibung: R-Spondin-1 (RSPO1) is the prototype member of the R-Spondin (RSPO) protein subfamily of a superfamily of thrombospondin type 1 repeat (TSR-1)-containing proteins (Chen <i>et al.</i>; Kamata <i>et al.</i>; Kazanskaya <i>et al.</i>; Kim <i>et al.</i>). Although unable to initialize signaling, RSPO family members are potent enhancers of WNT signaling (Cruciat and Niehrs; de Lau <i>et al.</i>; Kamata <i>et al.</i>; Kazanskaya <i>et al.</i>). They are characterized by a TSR-1 domain, a carboxy-terminal region with positively charged amino acids, and two N-terminal furin-like cysteine-rich repeats (Glinka <i>et al.</i>; Kazanskaya <i>et al.</i>). R­-Spondin-1 activates β­-catenin signaling via the WNT signaling cascade and by indirectly increasing low-density lipoprotein receptor-related protein 6 (LRP6) on the cell surface. It does this by binding leucine-rich repeat-containing G-protein-coupled receptor 5 (LGR5), and competing with WNT antagonist DKK­1 for binding to the WNT co­receptors, Kremen and LRP­6, which reduces DKK­1-­mediated internalization of LRP6 (Binnerts <i>et al.</i>). RSPO1 is involved in a wide range of pleiotropic roles during embryogenesis, it is required for the specification of hematopoietic stem cells, and it has been shown to be important in the growth, survival, and migration of ovarian cancer cells (Cruciat and Niehrs; de Lau <i>et al.</i>; Genthe and Clements; Liu <i>et al.</i>).

Lieferant: STEMCELL Technologies

Beschreibung: Vascular endothelial growth factor (VEGF-121) is a naturally-occurring VEGF-A splice variant involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 and VEGFR-2, and activates Raf/MEK/ERK and PI3K/AKT pathways. VEGF-121 is released as a freely diffusible protein by a variety of normal and transformed cells. It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum <i>et al.</i>). It has neurotrophic effects on neurons of the central nervous system and promotes growth and survival of dopaminergic neurons and astrocytes. VEGF also promotes growth and survival of vascular endothelial cells, monocyte chemotaxis, and colony formation by granulocyte-macrophage progenitor cells (Ferrara <i>et al.</i>).

Artikel-Nr: (STMC03801)

Lieferant: STEMCELL Technologies

Beschreibung: Myeloma and hybridoma culture medium (serum-containing).

UOM: 1 * 500 mL

Aktion

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Artikel-Nr: (STMC100-1382)

Lieferant: STEMCELL Technologies

Beschreibung: Stimulating T cells with SARS-CoV-2 (Spike Protein) Omicron/B.1.1.529 Mutation Peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. A lyophilised mixture of 80 peptides of the spike glycoprotein of SARS-CoV-2 Omicron variant (B.1.1.529), these peptides selectively cover the mutated regions in the spike protein of the SARS-CoV-2 Omicron variant, compared to wild-type. Through interactions with the angiotensin-converting enzyme 2 (ACE2) receptor, the spike protein enables the virus to attach to the cell membrane, and plays a critical role in viral entry (Hoffmann <i>et al.</i>; Walls <i>et al.</i>). Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

UOM: 1 * 1 LE

New Product Aktion

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Artikel-Nr: (ANKOTDF83)

Lieferant: ANKOM TECHNOLOGY

Beschreibung: This enzyme formulation was developed specifically for use in the ANKOMTDF dietary fiber analyser. With all of the necessary ingredients in this concentrated formula, just add the correct amount of water and the enzyme solution is ready for use in the instrument. This product has enough enzyme for approximately 500 ANKOMTDF dietary fiber analyser assays.

UOM: 1 * 100 mL

Zertifikate Aktion

Lieferant: STEMCELL Technologies

Beschreibung: The principal physiological regulator of erythropoiesis, Erythropoietin (EPO) is a glycoprotein growth factor that is produced primarily in the kidney in response to hypoxia or anemia. EPO promotes erythropoiesis by binding to a homodimeric cell surface receptor that activates JAK2/STAT5, PI3K/AKT, and MAPK pathways, and stimulates the proliferation and differentiation of erythroid progenitor cells (Jelkmann. Transfus Med Hemother, 2013; Kuhrt and Wojchowski. Blood, 2015).