Sie suchten nach: N(\u03B1)-Boc-D-tryptophan

5 823 results were found

Suchergebnis einschränken: Sortieren nach

Sort Results

Listenansicht Hybridansicht (NEU)

Vergleichen(0) Entfernen

Bewerten Sie das Suchergebnis

Human recombinant IDO (from E. coli)

Artikel-Nr: (PRSI92-695)

Lieferant: ProSci Inc.

Beschreibung: Indoleamine 2,3-dioxygenase (IDO) is a heme enzyme that initiates the oxidative degradation of the least abundant, essential amino acid, l-tryptophan, along the kynurenine pathway. This protein is normally expressed in the dendritic cells, macrophages, microglia, eosinophils, fibroblasts, endothelial cells, and most tumour cells. IDO activity is associated with immunosuppression and immune attenuation. Several studies showed that IDO can contribute to immune escape when expressed directly in tumour cells or when expressed in immunosuppressive antigen presenting cells such as tolerogenic dendritic cells or tumour associated macrophages. IDO also is a promising therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune suppression.

UOM: 1 * 50 µG

Aktion

N/A Stück

Natriummercaptoacetat (Natriumthioglycolat)

Lieferant: MP Biomedicals

Beschreibung: Sodium thioglycolate is a commonly used reagent for bacteriological research to maintain reducing conditions in media. Thioglycolate can also protect enzymes against inactivation by maintaining protein thiol groups in the reduced state. Thioglycolate medium is frequently used in inflammation research to elicit a neutrophil and macrophage response in vivo. Thioglycolic acid protects tryptophan in amino acid analysis,and also mediates formation of ATP from ADP. It lowers the oxidation-reduction potential and neutralises mercurial preservatives. An inhibitor of fatty acid oxidation. An agent that prevents the metabolism of fatty acids and stimulates feeding. The sodium salt form is typically used in production of bacteriological culture media.

Anti-IDO1 Mouse Monoclonal Antibody [clone: ID 177]

Artikel-Nr: (PRSI36-036)

Lieferant: ProSci Inc.

Beschreibung: IDO catalyzes the first and rate-limiting step in the main pathway of human tryptophan catabolism, the kynurenine pathway. Proinflammatory mediators, such as endotoxin and IFN-gamma induce the expression of IDO in several tissues. IDO-dependent suppression of T-cell responses might function as natural immunoregulatory mechanism. Physiological IDO activity has been implicated in T-cell tolerance to tumors, dysfunctional selftolerance in non-obese diabetic (NOD) mice, and as a protective negative regulator in autoimmune disorders.

UOM: 1 * 100 µG

Aktion

N/A Stück

Human recombinant Dihydropteridine Reductase (from cells)

Artikel-Nr: (PRSI91-662)

Lieferant: ProSci Inc.

Beschreibung: Dihydropteridine reductase, also known as HDHPR and Quinoid dihydropteridine reductase, QDPR and DHPR, belongs to the short-chain dehydrogenases/reductases (SDR) family. QDPR exists as a homodimer. QDPR is part of the pathway that recycles a substance called tetrahydrobiopterin, also known as BH4 and tryptophan hydroxylases. The regeneration of this substance is critical for the proper processing of several other amino acids in the body. Tetrahydrobiopterin also helps produce certain chemicals in the brain called neurotransmitters, which transmit signals between nerve cells. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C) which is a rare autosomal recessive disorder and is lethal.

UOM: 1 * 50 µG

Aktion

N/A Stück

Anti-QPCT Rabbit Polyclonal Antibody

Artikel-Nr: (PRSI26-343)

Lieferant: ProSci Inc.

Beschreibung: QPCT is responsible for the biosynthesis of pyroglutamyl peptides. QPCT has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. It also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-beta-amyloid. QPCT may be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides.This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UOM: 1 * 50 µG

Aktion

N/A Stück

Human recombinant Slc3A2 (from HEK293 cells)

Artikel-Nr: (PRSI96-138)

Lieferant: ProSci Inc.

Beschreibung: CD antigen CD98 is also known as 4F2 cell-surface antigen heavy chain (4F2hc), 4F2 heavy chain antigen, Solute carrier family 3 member 2 (SLC3A2), Lymphocyte activation antigen 4F2 large subunit, is a single-pass type I I membrane protein which belongs to the SLC3A transporter family.. SLC3A2 / CD98 is expressed ubiquitously in all tissues tested with highest levels detected in kidney, placenta and testis and weakest level in thymus. SLC3A2 / CD98 is required for the function of light chain amino-acid transporters and also involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. CD98 involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A5 or SLC7A8, CD98 involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals.

UOM: 1 * 100 µG

Aktion