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Image Unavailable-PRSI92-539

Mouse recombinant IFN gamma R1

Artikel-Nr: (PRSI92-539)
Lieferant: ProSci Inc.
Beschreibung: The tetrameric receptor complex for IFN gamma consists of two subunits, IFNGR1 (IFN gamma R alpha) and IFNGR2 (IFN gamma R beta ), through which the dimeric IFN- gamma exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFN gamma binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).
UOM: 1 * 50 µG
Image Unavailable-PRSI92-584

Mouse recombinant IL-12 R beta 2

Artikel-Nr: (PRSI92-584)
Lieferant: ProSci Inc.
Beschreibung: The IL12 receptor complex, formed by IL12RB1 and IL12RB2, mediates the type I immune responses of various types of lymphocytes. Its ligand, IL12, is a heterodimeric cytokine composed of IL-12p35 and IL-12p40 subunits that are linked via disulphide bonds. Ligation of IL-12 to its receptor involves the binding of IL-12p35 to IL12RB1 and IL-12p40 to IL12RB2. This will result in the activation of tyrosine kinase 2 (TYK2), which is associated with the IL12RB1 chain and Janus kinase 2 (JAK2), which is associated with the IL12RB2 chain. Activated TYK2 and JAK2 direct the phosphorylation of STAT4. IL12RB1 is present on all lymphocytes, while the expression of IL12RB2 is tightly regulated. It has shown that the expression of IL12RB2 is limited to Th2 cells. IL12RB2 subunit plays an important role in Th1 cell differentiation, since its absence leads to an abortive Th1 differentiation that has dysfunctional production of Th1 effector molecules.
UOM: 1 * 50 µG
Product Image-613-0968

Roboterspitzen für PerkinElmer® Janus®, Evolution P3, MiniTrak & PlateTrak®, Axygen®

Lieferant: Corning
Beschreibung: Frei von RNase, DNase und Pyrogen.

Image Unavailable-BOSSBS-2545R-HRP

Anti-IL2RG Rabbit Polyclonal Antibody (HRP (Horseradish Peroxidase))

Artikel-Nr: (BOSSBS-2545R-HRP)
Lieferant: Bioss
Beschreibung: Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.
UOM: 1 * 100 µl
Image Unavailable-PRSI92-538

Mouse recombinant IFN gamma R1

Artikel-Nr: (PRSI92-538)
Lieferant: ProSci Inc.
Beschreibung: The tetrameric receptor complex for IFN gamma consists of two subunits, IFNGR1 (IFN gamma R alpha) and IFNGR2 (IFN gamma R beta ), through which the dimeric IFN- gamma exerts its biological functions, including antiviral, antiproliferation and immune-modulatory activity in mammals. Both IFNGR1 and IFNGR2 are single transmembrane proteins belonging to the class II cytokine family. FNGR1, widely expressed in most host cells, is essential for IFN gamma binding, receptor trafficking, and signal transduction. IFNGR1 possesses an intracellular Janus tyrosine kinase (JAK) 1 binding site, a signal transducer and activator of transcription 1 (STAT1) binding site. The resulting STAT1 homodimers translocate from the cytoplasm to the nucleus and bind to the interferon-gamma activated sequence (GAS) promoter to induce expression of downstream interferon stimulated genes (ISGs).
UOM: 1 * 50 µG
Image Unavailable-PRSI90-394

Human recombinant CD40 (from CHO cells)

Artikel-Nr: (PRSI90-394)
Lieferant: ProSci Inc.
Beschreibung: CD40 is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 contains 4 cysteine-rich repeats in the extracellular domain and is expressed in B cells, dendritic cells, macrophages, endothelial cells and several tumour cell lines. The cognate interaction between CD40 and CD40 ligand (CD154) on T cells activates NF-kappaB, Jun N-terminal kinase and Janus kinase signal transducers and activators of transcription pathways. Several different TRAF proteins (adapter proteins) have been identified to serve as mediators of the signal transduction. In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation and thus is thought to be an early event in Alzheimer disease pathogenesis. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3), an autosomal recessive disorder characterised by the inability of B cells to undergo isotype switching, as well as an inability to mount an antibody-specific immune response and a lack of germinal center formation.
UOM: 1 * 100 µG
Product Image-STMC100-0932

Human Recombinant Leptin

Artikel-Nr: (STMC100-0932)
Lieferant: STEMCELL Technologies
Beschreibung: Leptin is a protein produced from the ob gene or lep gene, and acts as both a hormone involved in metabolic function as well as a proinflammatory cytokine by inducing Th1 immune responses (Dunn <i>et al.</i>; La Cava; Newman and Gonzalez-Perez). Leptin is a member of the gp130 family of cytokines and is known to be correlated with obesity (Dixit <i>et al.</i>; Dunn <i>et al.</i>). Leptin can both promote osteogenesis via osteoblast receptors and inhibit it through its actions on the hypothalamus (Figenschau <i>et al.</i>). It is a small, non-glycosylated protein with a highly conserved sequence between species. Leptin binds to the leptin receptor OB-R, which exists in six isoforms in humans and can activate various Janus kinase (JAK) and downstream pathways (Dunn <i>et al.</i>; Münzberg and Morrison; Newman and Gonzalez-Perez). For example, the binding of leptin to LepRb receptor activates JAK2, which leads to the phosphorylation of both JAK2 and the LepRb receptor, with three separate residues on the receptor triggering signaling pathways for SHP-2, STAT5, and STAT3 (Dunn <i>et al.</i>; Münzberg and Morrison). In addition to its effects on mature immune cells, other studies have suggested impacts on other cell types, with activities such as inducing cell proliferation and morphological differentiation in hematopoietic cell lines, chondrocytes, and hepatic cells (Figenschau <i>et al.</i>; Gainsford <i>et al.</i>; Santos-Alvarez <i>et al.</i>; Wang <i>et al.</i>).
UOM: 1 * 2 mg

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Product Image-AXYGRRF-175-C-R-S

Roboterspitzen für PerkinElmer® Janus (Roborack), Axygen®

Lieferant: Corning
Beschreibung: Transparentes oder schwarzes PP, mit oder ohne Filter, steril oder unsteril.

Environmentally Preferable

Product Image-STMC78085.2

Human Recombinant IL-9

Lieferant: STEMCELL Technologies
Beschreibung: Interleukin 9 (IL-9) has pleiotropic functions in the immune system and signals through its specific IL-9 receptor (IL-9R) (Renauld <i>et al.</i>). IL-9/IL-9R signaling pathway mainly targets the downstream activation of JAK/STAT (janus kinase/signal transducer and activator of transcription) and subsequent phosphorylation cascades initiated by multiple kinases including IRS–PI3K–PKB (insulin receptor substrate, phosphatidyl-inositol 3-kinases, protein kinase-B) and ERK (Knoops and Renauld; Fontaine <i>et al.</i>). IL-9 has been shown to have a role in Th1/Th17-mediated inflammation and in regulatory T cell responses (Singh <i>et al.</i>; Goswami and Kaplan). IL-9/IL-9R signaling pathway represents a novel endogenous anti-apoptotic mechanism for cortical neurons (Fontaine <i>et al.</i>). IL-9 secreting T cells, termed Th9 cells, contribute to both effective immunity and immunopathological disease, and have been shown to have a role in the treatment of allergic and autoimmune disease (Kaplan <i>et al.</i>).

Image Unavailable-1.01306.0025

Acid green 1 Indikator (C.I. 10020), Millipore®

Artikel-Nr: (1.01306.0025)
Lieferant: Merck
Beschreibung: Acid green 1 Indikator (C.I. 10020), Millipore®
UOM: 1 * 25 g

Sicherheitsdatenblätter


Product Image-HT70116-500ML

Methyl Green-Pyronin Y -Lösung, Sigma-Aldrich®

Artikel-Nr: (HT70116-500ML)
Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Pyronin stains the cytoplasm of plasma cells and most nucleoli red.
UOM: 1 * 500 mL
Image Unavailable-214566-50G

Alizarin Cyanin Green F ≥60 % (Farbstoffgehalt), Sigma-Aldrich®

Artikel-Nr: (214566-50G)
Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Acid Green 25, Dye content ≥60 %
UOM: 1 * 50 g
Image Unavailable-199583-25G

Acid green 50, Sigma-Aldrich®

Artikel-Nr: (199583-25G)
Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Lissamine Green B has been used in blood-brain barrier (BBB) studies and is used to study the its effect on herpes simplex virus 1 (HSV-1) corneal infection in animals.
UOM: 1 * 25 g
Image Unavailable-125660-25G

Leucomalachitgrün, Pulver, Sigma-Aldrich®

Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Leucomalachite green has been used as a reagent in presumptive tests which are used to detect invisible blood stains.

Image Unavailable-21980-500MG-F

Indocyaningrün für die Mikroskopie, Sigma-Aldrich®

Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: Cardiogreen was injected in animals intravenously for dynamic optical imaging system to study the capability of capturing the <i>in vivo</i> biodistribution kinetics.

Image Unavailable-I2633-100MG

Indocyaningrün, Sigma-Aldrich®

Lieferant: SIGMA ALDRICH MICROSCOPY
Beschreibung: A negatively charged polymethine dye that forms noncovalent fluorescent complexes with proteins.

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