Sie suchten nach: 3-Fluor-L-tyrosin

Artikel-Nr: (BOSSBS-1087R-A750)

Lieferant: Bioss

Beschreibung: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-12915R-A647)

Lieferant: Bioss

Beschreibung: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-12916R-A488)

Lieferant: Bioss

Beschreibung: c-Kit is a transmembrane tyrosine kinase encoded by the cKit proto oncogene. c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis and adhesion. Ligand binding to the extracellular domain leads to autophosphorylation on several tyrosine residues within the cytoplasmic domain, and activation. Mutations in c-Kit have been found to be important for tumor growth and progression in a variety of cancers including mast cell diseases, gastrointestinal stromal tumor, acute myeloid leukemia, Ewing sarcoma and lung cancer. Phosphorylation at tyrosine 721 of c-Kit allows binding and activation of PI3 kinase.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-0223R-A680)

Lieferant: Bioss

Beschreibung: catalyses the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-3182R-A555)

Lieferant: Bioss

Beschreibung: Gab2 (Grb2-associated binder-2) is an adaptor protein involved in numerous intracellular signaling pathways via its interaction with receptor tyrosine kinases (RTKs), growth factors and cytokines. Gab2 is a substrate of various RTKs, including EGFR, insulin receptor, cytokine receptors as well as B and T cell antigen receptors; Gab2 acts as a docking protein for several SH2-containing proteins. Upon tyrosine phosphorylation, Gab2 interacts with SHP2 tyrosine phosphatase and GRB2 adaptor protein PI3-kinase, CrkL and SHC.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-4123R-A750)

Lieferant: Bioss

Beschreibung: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. catalyses the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-3136R-A350)

Lieferant: Bioss

Beschreibung: Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-5175R-A555)

Lieferant: Bioss

Beschreibung: Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-5179R-A350)

Lieferant: Bioss

Beschreibung: Vital cellular functions such as cell proliferation and signal transduction are regulated in part by the balance between the activities of protein tyrosine kinases (PTK) and protein tyrosine phosphatases (PTPs). The protein contains a 121 residue extracellular domain, a single transmembrane segment, and 2 tandem intracytoplasmic catalytic domains. The PTP alpha protein is ubiquitously expressed and may play a fundamental role in the physiology of all cells.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-9187R-A680)

Lieferant: Bioss

Beschreibung: May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-4123R-A647)

Lieferant: Bioss

Beschreibung: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-1087R-A488)

Lieferant: Bioss

Beschreibung: Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-0223R-A750)

Lieferant: Bioss

Beschreibung: catalyses the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity).

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-0054R-A488)

Lieferant: Bioss

Beschreibung: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-0054R-A680)

Lieferant: Bioss

Beschreibung: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.

UOM: 1 * 100 µl

Aktion

Artikel-Nr: (BOSSBS-4086R-A750)

Lieferant: Bioss

Beschreibung: The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukaemia and in a subset of acute lymphoblastic leukaemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.

UOM: 1 * 100 µl

Aktion