Benzylalkohol, EMPROVE® EXPERT NF, JP, Ph. Eur., ChP, Sigma-Aldrich®
Lieferant: Merck
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Achtung
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Synonyme:
Benzenemethanol, Phenylmethanol, Phenylcarbinol
M-Clarity™ Qualitätsstufe = MQ500
1371201000
1371205000
1371209020
SIAL1371201000EA
0
EUR
SIAL1371201000
SIAL1371205000
SIAL1371209020
Benzylalkohol, EMPROVE® EXPERT NF, JP, Ph. Eur., ChP, Sigma-Aldrich®
Benzylalkohol
Benzyl alcohol is typically used as a preservative in liquid formulations and is active against bacteria, yeast and mould. It can also serve as a solvent for poorly soluble drugs. Benzyl Alcohol Emprove® Expert is an extraordinarily pure product with impurity specification thresholds even below current requirements of designated pharmacopoeias (e.g. benzaldehyde content <0,05%). Therefore, this product is especially suitable for high-risk applications or any other purpose that requires superior quality.
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Formel:
C₆H₅CH₂OH Molekulargewicht: 108.14 g/mol Siedepunkt: 203...205 °C (Lit.) Schmelzpunkt: –16...–13 °C (Lit.) Dichte: 1,045 g/ml (25 °C) (Lit.) Flammpunkt: 101 °C Lagerungstemperatur: Kühlschrank |
MDL Number:
MFCD00004599 CAS-Nummer: 100-51-6 EINECS: 202-859-9 Merck Index: 13,01126 |
Spezifikation Testergebnisse
| ASSAY (Ph.Eur/NF/JP) | 98.0 - 100.5% |
| ASSAY BY GC (ChP) | Anhydrous Basis |
| ID - IR (PhEur/NF/JP/ChP) | Conforms to reference spectrum |
| APPEARANCE (PhEur/NF/JP) | Clear, colourless, oily liquid |
| APPEARANCE – CLARITY (NF) | The sample shows the same clarity as that of water, or its opalescence is not more pronounced than that of Reference suspension 1 |
| APPEARANCE – COLOUR (NF) | The sample solution has the colour of water |
| APPEARANCE - COLOUR (PhEur) | The solution has the appearance of water and is not more intensely coloured than reference solution B9 |
| APPEARANCE - CLARITY (PhEur) | The sample shows the same clarity as that of water, or its opalescence is not more pronounced than that of Reference suspension 1 |
| APPEARANCE - CLARITY (JP) | The solution is clear and colourless |
| APPEARANCE - COLOUR (JP) | The solution is colourless |
| APPEARANCE - CLARITY (ChP) | Solution is clear |
| APPEARANCE - COLOUR (ChP) | The solution is colourless |
| REFRACTIVE INDEX | 1.538 - 1.541 |
| BOILING RANGE (LOWER)(ChP) | 203 - 206 °C |
| BOILING RANGE (UPPER)(ChP) | 203 - 206 °C |
| SPECIFIC GRAVITY/REL DENSITY(Ph. Eur | 1.043 - 1.049 |
| SPECIFIC GRAVITY/REL DENSITY (ChP) | 1.043 - 1.050 |
| RELATED SUBTANCES - GC: Benzaldehyde | ≤0.05% |
| RELATED SUBTANCES - GC: Cyclohexylmethanol | ≤0.10% |
| RELATED SUBTANCES - GC: Individual peaks with RRT less than that of Benzyl Alcohol | ≤0.02% |
| RELATED SUBST - GC (PhEur/JP): Individual peaks with RRT greater than that of Benzyl Alcohol | ≤0.10% |
| RELATED SUBST - GC (USP/NF): Individual peaks with RRT greater than that of Benzyl Alcohol | ≤0.05% |
| RELATED SUBTANCES - GC: Sum of other peaks with RRT less than that of Benzyl Alcohol | ≤0.02% |
| RELATED SUBTANCES - GC: Sum of other peaks with RRT greater than that of Benzyl Alcohol | ≤0.2% |
| RELATED SUBTANCES - GC: Total Impurities | ≤0.37% |
| RELATED SUBST - GC (ChP): Total Impurities (except benzaldehyde) | ≤0.01% |
| RELATED SUBST - GC (ChP): Total Impurities | ≤0.05% |
| OTHER RELATED SUBSTANCES BY GC Benzene | ≤0.0001% |
| OTHER RELATED SUBSTANCES BY GC: Benzyl Chloride | ≤0.005% |
| OTHER RELATED SUBSTANCES BY GC: Dibenzyl Ether | ≤0.05% |
| PEROXIDE VALUE (PhEur/NF/JP) | ≤5 |
| CHLORIDE (ChP) | ≤0.003% |
| ACIDITY (PhEur/NF): 0.1M NaOH required to change the colour to pink | ≤1 ml |
| ACIDITY (JP): 0.1 M sodium hydroxide required | ≤1 ml |
| ACIDITY (ChP) | ≤0.2 ml |
| RESIDUE ON EVAPORATION | ≤0.05% |
| WATER CONTENT | ≤0.1% |
| ENDOTOXINS (SAFC) | ≤2.5 IU/ml |
| ENDOTOXINS (ChP): IU/mg. Limit of ≤0.04 set to align with ChP Chinese Language Version limit of <0.1IU/mg | ≤0.04 |
| TOTAL AEROBIC MICROBIAL COUNT | ≤100 CFU/ml |
| TOTAL YEAST AND MOULD COUNT | ≤10 CFU/ml |
| RESIDUAL SOLVENTS: No organic solvents are used in the process | |
| ELEMENTAL IMPURITIES: No elemental impurities exceeded the control threshold of option 1 limit as stated in ICH Q3D |
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