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Combining gases, solids, or other liquids with a solvent, dissolution apparatuses optimize pharmaceutical formulation. Providing quality control and batch consistency, the equilibrium disintegrating machines provide critical in vitro drug release information. Completed tests serve as safe surrogates for human studies when establishing proficient medical products and the predictive models generated will support manufacturing approvals. Up-to-date dissolution apparatuses complete with hemispheric vessel and rotating spindle, provide suitable conditions for optimal performance testing.